according to Frontline's website FAQ question #7 states: FRONTLINE Brand Products do not carry an expiration date. We recommend storing FRONTLINE Brand Products at room temperature and keeping them sealed in their original packaging. If stored under these conditions, FRONTINE Brand Products will not expire.

Yes, but the product must dry before a bath or swimming. “Waterproof” is also listed on the front of package.

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FRONTLINE Frontline Plus Blue 23 - 44 Lb Med 3pk

FRONTLINE Frontline Plus Blue 23 - 44 Lb Med 3pk

Q: If my dog is 22 do I buy up to 22 or go to the second category 23 up?

I am in the same situation. I have found that the smaller dose is not effective. But the 23 and up does the trick.

Q: Does it actually work ?

We've used this product in the past and it worked, and we live on a corner and have our dogs in the country and camping in wooded areas. If I remember correctly, it won't kill adult fleas, but prevents them from reproducing and I believe the nuts as well. If there's an infestation, or a source of fleas nearby, even a neighbor animal, that doesn't have the flea problem addressed, the flea cycle will continue.